Publications

bale lab
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Stress increases sperm respiration andmotility in mice and men

Moon N, Morgan CP, Marx-Rattner R, Jeng A, Johnson RL, Chikezie I, Mannella C, Sammel MD, Epperson CN, Bale TL. Stress increases sperm respiration and motility in mice and men. Nat Commun 15, 7900 (2024). doi: 10.1038/s41467-024-52319-0
2024

Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects

Montgomery KR, Bridi MS, Folts LM, Marx-Rattner R, Zierden HC, Wulff AB, Kodjo EA, Thompson SM, Bale TL. Neuropsychopharmacology. 2023 Oct 13. doi: 10.1038/s41386-023-01739-5. Epub ahead of print. PMID: 37833589.
2023

Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy

Zierden HC, Marx-Rattner R, Rock KD, Montgomery KR, Anastasiadis P, Folts L, Bale TL. Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy. Sci Rep. 2023 Mar 20;13(1):4568. doi: 10.1038/s41598-023-31425-x. PMID: 36941297; PMCID: PMC10027885.
2023

Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specifc manner

Duffy KA, Sammel MD, Johnson RL, Kim DR, Wang EY, Ewing G, Hantsoo L, Kornfield SL, Bale TL, Epperson CN. Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner. Biol Sex Differ. 2023 Feb 17;14(1):7. doi: 10.1186/s13293-023-00492-0. PMID: 36803442; PMCID: PMC9936707.
2023

HA‐tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception

Morgan CP, Meadows VE, Marx-Rattner R, Cisse YM, Bale TL. HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception. Sci Rep. 2023 Jan 13;13(1):707. doi: 10.1038/s41598-023-27898-5. PMID: 36639735; PMCID: PMC9839718.
2023

What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons

Cole AB, Montgomery K, Bale TL, Thompson SM. What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons. Neurobiol Stress. 2022 Aug 5;20:100473. doi: 10.1016/j.ynstr.2022.100473. PMID: 35982732; PMCID: PMC9379952.
2022

Developmental timing of trauma in women predicts unique extracellular vesicle proteome signatures

Morrison KE, Stenson AF, Marx-Rattner R, Carter S, Michopoulos V, Gillespie CF, Powers A, Huang W, Kane MA, Jovanovic T, Bale TL. Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures. Biol Psychiatry. 2022 Feb 1;91(3):273-282. doi: 10.1016/j.biopsych.2021.08.003. Epub 2021 Aug 17. PMID: 34715991; PMCID: PMC9219961.
2022

Germ Cell Drivers: Transmission of Preconception Stress Across Generations

Duffy KA, Bale TL, Epperson CN. Germ Cell Drivers: Transmission of Preconception Stress Across Generations. Front Hum Neurosci. 2021 Jul 12;15:642762. doi: 10.3389/fnhum.2021.642762. PMID: 34322003; PMCID: PMC8311293.
2021

The critical importance in identifying the biological mechanisms underlying the effects of racism on mental health

Bale TL, Jovanovic T. The critical importance in identifying the biological mechanisms underlying the effects of racism on mental health. Neuropsychopharmacology. 2021 Jan;46(1):233. doi: 10.1038/s41386-020-00801-w. PMID: 32792682; PMCID: PMC7424557.
2021

Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs

Morgan CP, Shetty AC, Chan JC, Berger DS, Ament SA, Epperson CN, Bale TL. Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs. Sci Rep. 2020 Oct 15;10(1):17498. doi: 10.1038/s41598-020-73867-7. PMID: 33060642; PMCID: PMC7562703.
2020

Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific

Cissé YM, Chan JC, Nugent BM, Banducci C, Bale TL. Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific. Placenta. 2020 Oct;100:164-170. doi: 10.1016/j.placenta.2020.06.019. Epub 2020 Jul 12. PMID: 32980048; PMCID: PMC7525040.
2020

Microphysiological systems of the placental barrier

Arumugasaamy N, Rock KD, Kuo CY, Bale TL, Fisher JP. Microphysiological systems of the placental barrier. Adv Drug Deliv Rev. 2020;161-162:161-175. doi: 10.1016/j.addr.2020.08.010. Epub 2020 Aug 26. PMID: 32858104; PMCID: PMC10288517.
2020

Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression

Ramsteijn AS, Jašarević E, Houwing DJ, Bale TL, Olivier JD. Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression. Gut Microbes. 2020 Jul 3;11(4):735-753. doi: 10.1080/19490976.2019.1705728. Epub 2020 Jan 23. PMID: 31971855; PMCID: PMC7524305.
2020

Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain

Morrison KE, Cole AB, Kane PJ, Meadows VE, Thompson SM, Bale TL. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology. 2020 Jul;45(8):1263-1271. doi: 10.1038/s41386-020-0634-y. Epub 2020 Feb 11. PMID: 32045935; PMCID: PMC7297802.
2020

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Chan JC, Morgan CP, Adrian Leu N, Shetty A, Cisse YM, Nugent BM, Morrison KE, Jašarević E, Huang W, Kanyuch N, Rodgers AB, Bhanu NV, Berger DS, Garcia BA, Ament S, Kane M, Neill Epperson C, Bale TL. Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment. Nat Commun. 2020 Mar 20;11(1):1499. doi: 10.1038/s41467-020-15305-w. PMID: 32198406; PMCID: PMC7083921.
2020

Brexanolone for the treatment of patients with postpartum depression

Morrison KE, Cole AB, Thompson SM, Bale TL. Brexanolone for the treatment of patients with postpartum depression. Drugs Today (Barc). 2019 Sep;55(9):537-544. doi: 10.1358/dot.2019.55.9.3040864. PMID: 31584571; PMCID: PMC8033597.
2019

The critical importance of basic animal research for neuropsychiatric disorders

Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2. PMID: 31048727; PMCID: PMC6784904.
2019

Driving the next generation: Paternal lifetime experiences transmitted via extracellular vesicles and their small RNA cargo

Morgan CP, Chan JC, Bale TL. Driving the Next Generation: Paternal Lifetime Experiences Transmitted via Extracellular Vesicles and Their Small RNA Cargo. Biol Psychiatry. 2019 Jan 15;85(2):164-171. doi: 10.1016/j.biopsych.2018.09.007. Epub 2018 Sep 27. PMID: 30580777; PMCID: PMC6309802.
2019

Sex matters

Bale TL. Sex matters. Neuropsychopharmacology. 2019 Jan 1;44(1):1-3. doi: 10.1038/s41386-018-0239-x.
2019

Placental H3K27me3 establishes female resilience to prenatal insults

Nugent BM, O'Donnell CM, Epperson CN, Bale TL. Placental H3K27me3 establishes female resilience to prenatal insults. Nat Commun. 2018 Jul 2;9(1):2555. doi: 10.1038/s41467-018-04992-1. PMID: 29967448; PMCID: PMC6028627.
2018

Parental advisory: maternal and paternal stress can impact offspring neurodevelopment

Chan JC, Nugent BM, Bale TL. Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment. Biol Psychiatry. 2018 May 15;83(10):886-894. doi: 10.1016/j.biopsych.2017.10.005. Epub 2017 Oct 13. PMID: 29198470; PMCID: PMC5899063.
2018

Strained in Planning Your Mouse Background? Using the HPA Stress Axis as a Biological Readout for Backcrossing Strategies

Chan JC, Houghton AB, Bale TL. Strained in Planning Your Mouse Background? Using the HPA Stress Axis as a Biological Readout for Backcrossing Strategies. Neuropsychopharmacology. 2017 Aug;42(9):1749-1751. doi: 10.1038/npp.2017.66. Epub 2017 Mar 31. PMID: 28361869; PMCID: PMC5520787.
2017

Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating

Bronson SL, Chan JC, Bale TL. Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating. Biol Psychiatry. 2017 Jul 15;82(2):127-138. doi: 10.1016/j.biopsych.2016.12.025. Epub 2016 Dec 30. PMID: 28168960; PMCID: PMC5483189.
2017

Preadolescent adversity programs a disrupted maternal stress reactivity in humans and mice

Morrison KE, Epperson CN, Sammel MD, Ewing G, Podcasy JS, Hantsoo L, Kim DR, Bale TL. Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice. Biol Psychiatry. 2017 Apr 15;81(8):693-701. doi: 10.1016/j.biopsych.2016.08.027. Epub 2016 Aug 26. PMID: 27776734; PMCID: PMC5326692.
2017

Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition

Epperson CN, Sammel MD, Bale TL, Kim DR, Conlin S, Scalice S, Freeman K, Freeman EW. Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition. J Clin Psychiatry. 2017 Mar;78(3):e298-e307. doi: 10.4088/JCP.16m10662. PMID: 28394509.
2017

Sex as a Biological Variable: Who, What, When, Why, and How

Bale TL, Epperson CN. Sex as a Biological Variable: Who, What, When, Why, and How. Neuropsychopharmacology. 2017 Jan;42(2):386-396. doi: 10.1038/npp.2016.215. Epub 2016 Sep 23. PMID: 27658485; PMCID: PMC5399243.
2017

The placenta and neurodevelopment: sex differences in prenatal vulnerability

Bale TL. The placenta and neurodevelopment: sex differences in prenatal vulnerability. Dialogues Clin Neurosci. 2016 Dec;18(4):459-464. doi: 10.31887/DCNS.2016.18.4/tbale. PMID: 28179817; PMCID: PMC5286731.
2016

Sex differences in the gut microbiome – brain axis across the lifespan

Jašarević E, Morrison KE, Bale TL. Sex differences in the gut microbiome-brain axis across the lifespan. Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19;371(1688):20150122. doi: 10.1098/rstb.2015.0122. Epub 2016 Feb 1. PMID: 26833840; PMCID: PMC4785905.
2016

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

Rodgers AB, Morgan CP, Leu NA, Bale TL. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13699-704. doi: 10.1073/pnas.1508347112. Epub 2015 Oct 19. PMID: 26483456; PMCID: PMC4640733.
2015

Sex differences and stress across the lifespan

Bale TL, Epperson CN. Sex differences and stress across the lifespan. Nat Neurosci. 2015 Oct;18(10):1413-20. doi: 10.1038/nn.4112. Epub 2015 Sep 25. PMID: 26404716; PMCID: PMC4620712.
2015

Germ cell origins of PTSD risk: the transgenerational impact of parental stress experience

Rodgers AB, Bale TL. Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience. Biol Psychiatry. 2015 Sep 1;78(5):307-14. doi: 10.1016/j.biopsych.2015.03.018. Epub 2015 Mar 23. PMID: 25895429; PMCID: PMC4526334.
2015

Epigenetic and transgenerational reprogramming of brain development

Bale TL. Epigenetic and transgenerational reprogramming of brain development. Nat Rev Neurosci. 2015 Jun;16(6):332-44. doi: 10.1038/nrn3818. Epub 2015 Apr 29. PMID: 25921815; PMCID: PMC7064155.
2015

Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms

Kim DR, Bale TL, Epperson CN. Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep. 2015 Feb;17(2):5. doi: 10.1007/s11920-014-0546-9. PMID: 25617041; PMCID: PMC4458064.
2015

Lifetime stress experience: transgenerational epigenetics and germ cell programming

Bale TL. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues Clin Neurosci. 2014 Sep;16(3):297-305. doi: 10.31887/DCNS.2014.16.3/tbale. PMID: 25364281; PMCID: PMC4214173.
2014

Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction

Howerton CL, Bale TL. Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9639-44. doi: 10.1073/pnas.1401203111. Epub 2014 Jun 16. PMID: 24979775; PMCID: PMC4084439.
2014

Epigenetic mechanisms in pubertal brain maturation

Morrison KE, Rodgers AB, Morgan CP, Bale TL. Epigenetic mechanisms in pubertal brain maturation. J Neurosci. 2014 Apr 4;264:17-24. doi: 10.1016/j.neuroscience.2013.11.014. Epub 2013 Nov 15. PMID: 24239720; PMCID: PMC3959229.
2014

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms OffspringHPAStress Axis Regulation

Rodgers AB, Morgan CP, Bronson SL, Revello S, Bale TL. Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J Neurosci. 2013 May 22;33(21):9003-12. doi: 10.1523/JNEUROSCI.0914-13.2013. PMID: 23699511; PMCID: PMC3712504.
2013

Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit

Bale TL, Chen A. Minireview: CRF and Wylie Vale: a story of 41 amino acids and a Texan with grit. Endocrinology. 2012 Jun;153(6):2556-61. doi: 10.1210/en.2012-1273. Epub 2012 Apr 4. PMID: 22492308; PMCID: PMC3359597.
2012

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

Morgan CP, Bale TL. Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci. 2011 Aug 17;31(33):11748-55. doi: 10.1523/JNEUROSCI.1887-11.2011. PMID: 21849535; PMCID: PMC3164823.
2011

Sex differences in prenatal epigenetic programing of stress pathways

Bale TL. Sex differences in prenatal epigenetic programming of stress pathways. Stress. 2011 Jul;14(4):348-56. doi: 10.3109/10253890.2011.586447. PMID: 21663536.
2011

Early life programming and neurodevelopmental disorders

Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15;68(4):314-9. doi: 10.1016/j.biopsych.2010.05.028. PMID: 20674602; PMCID: PMC3168778.
2010